Dietary Intake, Fatty Acid Profile in Plasma and Neutrophil Phospholipids, and Serum Antioxidant Levels in Patients with Crohn's Disease

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Title
Dietary Intake, Fatty Acid Profile in Plasma and Neutrophil Phospholipids, and Serum Antioxidant Levels in Patients with Crohn's Disease
Author
著者 Kawakamil Yuko
著者(別表記)
著者 Okada Hiroyuki
著者(別表記)
Abstract

To elucidate the efficacy of dietary therapy for Crohn's disease, we analyzed dietary intake, fatty acid composition of phospholipids in plasma and neutrophils, serum fat-soluble vitamin levels, and oxygen radical absorbance capacity in twenty Crohn's disease patients (15 males and 5 females, 11 with ileitis and 9 with ileocolitis, 30.6k8.2 year), who were treated at the Department of Gastroenterology of Okayama University Hospital. Total fat intake, fat energy ratio and linoleic
acid intake were significantly lower, while protein and carbohydrate intakes were significantly higher, in the patients than in age and sex-matched controls. In the neutrophil phospholipids of Crohn's disease patients, significantly higher levels of total n-6 polyunsaturated fatty acid and lower levels of docosahexaenoic acid were observed. The concentrations of serum retinol and 8-carotene but not a-tocopherol were significantly lower and serum oxygen radical absorbance capacity was also lower than in the controls. Significant correlations between serum oxygen radical absorbance capacity and zinc (~0.797, p<0.001) concentrations were observed in the Crohn's disease patients. A diet restricting the intake of n-6 polyunsaturated fatty acid and antioxidative trace minerals and vitamins may be recommended for the nutritional management of Crohn's disease patients.

Subject
490 Medical sciences. Pharmaceutics
Keyword
Crohn's disease
diet
fatty acid
trace mineral
fat-soluble vitamin
neutrophil fatty acid
Note

この論文は国立情報学研究所によって電子化された。

Publish Date
2007
Publication Title
Chugokugakuen journal
Volume
6
Start Page
11
End Page
16
ISSN
1348-1452
NCID
AA11806612
Publisher
中国学園大学/中国短期大学
Copyright Holders
中国学園大学/中国短期大学
Official URL
Contents Type
Departmental Bulletin Paper
language
English
File Version
publisher