Genomic structure and sequence of a chicken homolog (chNthl1) of Escherichia coli endonuclease III with those of the adjacent parts of chTsc2 and chSlc9a3r2 genes

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Title
Genomic structure and sequence of a chicken homolog (chNthl1) of Escherichia coli endonuclease III with those of the adjacent parts of chTsc2 and chSlc9a3r2 genes
Author
著者 Seki Shuji
著者(別表記)
著者 Sarke Altaf H.
著者(別表記)
著者 Nakamura Takashi
著者(別表記)
著者 Seki Yuichi
著者(別表記)
著者 Ikeda Shogo
著者(別表記)
Abstract

Genomic cloning and sequencing of a chicken homolog (chNthll) for Escherichia coli endonuclease Ⅲ, that is involved in pyrimidine base excision repair, were performed. The sequence covered the entire chNthll gene consisting of six exons and five introns spanning 4.9kb with 5' flanking (6.6kb) and 3' flanking (3.lkb) regions. The boundaries between exon and intron follow the GT/AG rule. The sequenced 5' flanking region lacks typical TATA and CAAT boxes, but contains a CpG island having putative binding sites for several transcription factors such as Ests 1 and Spl. The chNthll gene lies immediately adjacent to the tuberous sclerosis 2 (chTsc2) gene in a 5'-to-5' orientation. Downstream of the chNthll gene, the gene for the regulatory factor 2 (chSlc9a3r2) of the solute carrier
family 9 (sodium/hydrogen exchanger), isoform A3, lies in a 3'-to-3' orientation. The genomic organization of the chNthll gene and the relative orientation of the gene with the adjacent genes of chTsc2 and chSlc9a3r2 are similar to those in human and mouse genomes.

Subject
460 Biology
490 Medical sciences. Pharmaceutics
Keyword
chicken Nth11 gene
genomic cloning
endonucleaselII homolog
chicken
Note

この論文は国立情報学研究所によって電子化された。

Publish Date
2007
Publication Title
Chugokugakuen journal
Volume
6
Start Page
23
End Page
27
ISSN
1348-1452
NCID
AA11806612
Publisher
中国学園大学/中国短期大学
Copyright Holders
中国学園大学/中国短期大学
Official URL
Contents Type
Departmental Bulletin Paper
language
English
File Version
publisher